Engineered NK cell manufacturing service – Proven solutions for new frontiers in cell and gene therapy

The CliniMACS Prodigy® NK Cell Transduction (NKCT) Process simplifies and standardizes the manufacture of CAR NK cells. Our automated, closed system addresses the key challenges of scalability, speed, and GMP compliance, enabling efficient and reproducible manufacturing from early development through to commercialization. Proven in numerous clinical programs, the platform reduces manual steps, minimizes variability, and shortens time-to-clinic. Partner with us and turn new frontiers into proven solutions.

Expertise you can trust
 

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Transduction efficiency of 
60–80% of NK cells when using our BaEV LVV Platform*

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8 allogeneic assets supported 

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Ability to expand to 
1.7 × 109 total NK cells

 *In experiments run across 3 donors and multiple constructs. Based on data collected through 2024. 
Miltenyi Biotec does not guarantee any specific results, or that batches will fully conform with any particular specifications.  Individual success rate may vary based on factors such as client specifications.

Leverage our expertise in NK cell engineering

  • Experience with engineered & non-engineered NK cell programs
  • As standard or as custom as you need
  • Standardized processes increase reproducibility and scalability while reducing the complexity of CAR NK cell manufacturing
  • Ability to connect the CliniMACS Prodigy to external culture vessels for large-scale closed manufacturing of allogeneic therapies
Illustration showing the comparison of transducing titers between client plasmids vs. Miltenyi-optimized designs
Efficient clinical-grade NK cell separation on the CliniMACS Prodigy Platform. 

Excellent NK cell enrichment

Our two-step clinical-grade NK cell separation process efficiently removes T cells via CD3+ cell depletion and purifies NK cells via CD56+ cell enrichment. The resulting cell product consists of highly pure and viable NK cells, with a minimal presence of other immune cell types.

Download the brochure on our NK cell manufacturing solutions.

Illustration showing the comparison of transducing titers between client plasmids vs. Miltenyi-optimized designs
NK cell transduction performance on the CliniMACS Prodigy Platform

Highly efficient NK cell transduction

Our automated CliniMACS Prodigy NK Cell Transduction Process has been validated in industry and numerous clinical studies. It is designed for standardized and reliable cell manufacturing, delivering excellent transduction efficiencies and target cell frequencies.

What you can expect:

  • Consultative & collaborative approach to process and analytical development
  • Option to leverage pre-defined cell processing and analytical packages
  • Phase appropriate but scalable solutions
  • Flexible clinical manufacturing in ballroom suites
  • Comprehensive regulatory support

Interested in more information? Get the details!

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